|Courtesy of Ridurey1|
When opened, the reader and 1d6-2 other individuals within 15' of the Book of Nothing must make a save -5. Success incurs 1d6+2 HP damage, and a permanent loss of 1 Constitution point.
Any who fail the save have their soul trapped within the Book of Nothing. Their Wisdom and Intelligence scores drop to 3, and their eyes become shadowy orbs. Destruction of the book is not enough to reclaim the victims' souls, only intervention from a higher power (either through direct intervention or a Crusader's Miracle) can restore those claimed by Nothing.